Guides Collective
The Weekly Guide
Resources, research, and reflections — curated each week for the guides in our community.
MAY 27, 2026
Section 01
Industry Headlines
What's happening in the psychedelic space this week.
MEDICALXPRESS · MAY 5, 2026
One Dose of Psilocybin Changes the Human Brain, Leading to Higher Entropy
A landmark study from UCSF and Imperial College London found that a single dose of psilocybin produces measurable changes in brain connectivity — increasing neural entropy in ways associated with lasting improvements in mood and cognition.
COMPASS PATHWAYS · FEBRUARY 17, 2026
Psilocybin Passes Second Phase 3 Trial — Compass Pathways Eyes FDA Filing in Q4 2026
Compass Pathways announced that COMP360 psilocybin met its primary endpoint in a second Phase 3 trial for treatment-resistant depression — with 39% of participants in the 25 mg arm showing clinically meaningful symptom reduction and rapid onset beginning the day after a single dose. The company plans to file a New Drug Application with the FDA in Q4 2026, potentially making psilocybin the first approved psychedelic treatment for depression.
MEDICALXPRESS · MAY 4, 2026
Cannabis Leads US Microdosing, With 24.1 Million Adults Reporting Lifetime Use
A University of California San Diego study found that 24.1 million American adults have tried microdosing cannabis — with growing use among those seeking mental health benefits and performance enhancement.
Section 02
From the Field
Perspectives and insights from leaders in the psychedelic space.
A.C. Redick · Lucid News
Learning to Die Well: Inside a Psychedelic End-of-Life Retreat
Reverend Bodhi Be's vision for transforming end-of-life care materialized through the inaugural retreat of the Ram Dass Institute of Psychedelic Studies with the Dying — bringing seventy practitioners to Maui to explore how psychedelics can support conscious dying.
Jack Gorsline · Lucid News
Evaluating the Pros and Cons of State Psychedelic Task Forces
States are increasingly establishing task forces to study psychedelic-assisted therapies — with some jurisdictions seeing recommendations translate into action while others face criticism for using commissions to delay rather than accelerate meaningful reform.
Section 03
Personal Journeys
First-person accounts worth reading — perspectives that inform the work we do.
LUCID NEWS · MAY 13, 2026
Football Player Jordan Poyer Leads the Breath of Life Tour
Former NFL safety Jordan Poyer documents his journey organizing the Breath of Life Tour — bringing breathwork and somatic healing practices to communities across the country in the wake of his own transformative recovery experience.
NORMALIZE PSYCHEDELICS · MAY 7, 2026
The Spider Speaks: Healing From Childhood Sexual Abuse Through Plant Medicine and the Ring
A survivor of childhood sexual abuse shares how a combination of plant medicine ceremonies and combat sports became an unexpected path toward integration, reclaiming the body, and finding a language for trauma that years of conventional therapy could not reach.
Section 04
From the Platform
What's new and coming to Guides Collective.
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